You are viewing a preview of this job. Log in or register to view more details about this job.

Medicinal Chemistry Intern - Summer 2021

CARDINAL INTERNSHIP: South San Francisco. Not indicated to be remote at this time. A Wes parent at ORIC wants Wes students and 2020 grads to apply for this paid summer position. Outstanding professional development opportunity. Apply immediately.

TO APPLY: apply with your approved resume through Handshake. Include a brief cover letter (two paragraphs) explaining your qualifications and your specific interest in ORIC's work.

ORIC Pharmaceuticals, Inc, is a clinical stage oncology company dedicated to improving patients’ lives and focused on developing treatments that address mechanisms of therapeutic resistance. We are excited to offer an 8-10 week paid summer internship in the Medicinal Chemistry group to a highly motivated student or 2020 grad studying synthetic organic chemistry or a closely related field. We are proud to bring enthusiastic candidates into our teams, to provide them with an opportunity to contribute to meaningful projects, while building a foundation for their future career. This position provides the opportunity to obtain hands-on biotechnology experience while contributing in the laboratory to design and synthesis of compounds that will be evaluated in biological assays for cancer. The ideal applicant will have a passion for organic chemistry and an interest in learning how it applies to the field of Medicinal Chemistry for the discovery of new therapeutics for cancer.

Responsibilities:
  • The intern will have the opportunity to synthesize, purify, and characterize novel biologically-active molecules
  • Propose multi-step synthetic sequences and generate intermediates and target compounds
  • Operate laboratory equipment, utilizing appropriate methods for performing experiments
  • Purify products via column chromatography or reverse-phase HPLC
  • Acquire and interpret analytical data (e.g. HPLC, LCMS and NMR)
  • Learn to use literature and protocol searching tools (e.g. SciFinder)
  • Opportunity to gain hand-on experience with molecular modeling and data visualization software tools
  • Contribute to exploratory research projects and collaborate with other members of the group
  • Keep excellent records of experimental procedures and acquired data in an electronic notebook
  • Attend relevant project meetings and present your work in chemistry meetings

Qualifications:
  • Major in Chemistry, Chemical Biology or related field (we will consider undergraduate or graduate students with relevant experience)
  • Previous hands-on laboratory experience in synthetic organic chemistry is strongly preferred
  • Experienced in obtaining and analyzing relevant analytical data, such as NMR, LCMS or HPLC
  • Organized, detail-oriented, creative thinker, self-motivated with a strong desire to learn
  • Excellent verbal and written communication skills
  • Ability to work independently and as part of a team

About ORIC Pharmaceuticals:
ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with (1) Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid tumors. ORIC’s other product candidates include (1) ORIC-533, an orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy- and immunotherapy-based treatment regimens, (2) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (3) ORIC-114, a brain penetrant inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations, being developed across multiple genetically defined cancers. Beyond these four product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to http://oricpharma.com/.